parC [2017-12-06 13:21:37]

subunit of DNA topoisomerase IV

Locus: BSU18100

Isoelectric point: 6.31

Molecular weight: 91.14 kDa

Protein length: 806 aa

Gene length: 2418 bp

Function: chromosome segregation and compaction

Product: subunit of DNA topoisomerase IV

Essential: yes

E.C.: 5.99.1.-

Synonyms: grlA

Genomic Context

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Categories containing this gene/protein

• Information processing → Genetics → DNA condensation/ segregation
• Groups of genes → Essential genes

Gene

Coordinates: 1,935,448 → 1,937,868

Phenotypes of a mutant

• essential PubMed
• a parC point mutation has been isolated upon selction at low pressure PubMed

The protein

Protein family

• topoisomerase gyrA/parC subunit family (according to Swiss-Prot)

Paralogous protein(s)

• GyrA

Structure

• 1WP5 (C-terminal domain, Geobacillus stearothermophilus)

Localization

• cytoplasm (Homogeneous) PubMed
• polar localization in actively growing cells PubMed

Expression and Regulation

Operons

• Genes: parE-parC
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • LexA: repression, PubMed, in LexA regulon

  Regulation

  • induced by DNA damage (LexA) PubMed

  Additional information

  • term-seq has identified a potential novel regulatory RNA element including an intrinsic transcription terminator upstream of parE PubMed

References

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